| Identification | Back Directory | [Name]
Moveltipril calcium | [CAS]
85921-53-5 | [Synonyms]
MC 838
altiopril calcium
MOVELTIPRIL CALCIUM
Moveltipril calcium salt
Bis[1-[(S)-3-[[(R)-2-(cyclohexylcarbonylamino)propanoyl]thio]-2-methylpropanoyl]-L-proline]calcium salt
Bis[1-[(S)-3-[[(R)-2-[(cyclohexylcarbonyl)amino]-1-oxopropyl]thio]-2-methyl-1-oxopropyl]-L-proline]calcium salt
Calcium (S)-1-((S)-3-(((R)-2-(cyclohexanecarboxamido)propanoyl)thio)-2-methylpropanoyl)pyrrolidine-2-carboxylate
Calcium (2R)-1-[(2R)-3-[2-(cyclohexanecarbonylamino)propanoylsulfanyl]-2-methylpropanoyl]pyrrolidine-2-carboxylate | [Molecular Formula]
2(C19H29N2O5S).Ca | [MDL Number]
MFCD01698803 | [MOL File]
85921-53-5.mol | [Molecular Weight]
835.1 |
| Hazard Information | Back Directory | [Uses]
Moveltipril calcium (MC-838 calcium) is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moveltipril calcium binds via a stable thioester bond and exhibits relative resistance to enzymatic hydrolysis in rat liver homogenate. Moveltipril calcium effectively inhibits ACE extracted from rabbit lung in a concentration-dependent manner. Moveltipril calcium is able to highly specifically inhibit the contractile response to angiotensin-I (AI) in free rat aortic rings and guinea pig ileum preparations, while enhancing the contractile response to calcitonin[1]. | [References]
[1] MC-838 (altiopril calcium): a novel orally active angiotensin converting enzyme inhibitor |
| Safety Data | Back Directory | [Toxicity]
LD50 in male, female mice, male, female rats (g/kg): all >10.0 orally; 2.1, 2.3, 1.3, 1.3 i.p.; 3.0, 3.8, 3.4, 3.9 s.c.; and in male, female dogs (g/kg): >6.0, >6.0 orally (Sakai) |
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| Company Name: |
Wonda Science
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| Tel: |
+1 (514) 581-6866 |
| Website: |
www.wondascience.com |
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