| Identification | Back Directory | [Name]
thenalidine | [CAS]
86-12-4 | [Synonyms]
Sandostene
Thenalidin
Thenaldine
thenalidine
Thenophenopiperidine
1-Methyl-4-[phenyl(2-thienylmethyl)amino]piperidine | [EINECS(EC#)]
201-651-5 | [Molecular Formula]
C5H6N2S | [MDL Number]
MFCD00865681 | [MOL File]
86-12-4.mol | [Molecular Weight]
126.18 |
| Chemical Properties | Back Directory | [Melting point ]
95-97° | [Boiling point ]
bp0.02 158-160° | [density ]
1.140±0.06 g/cm3(Predicted) | [pka]
pKa 3.36±0.06(H2O
t undefined
I = 0.30
(NaCl)) (Uncertain);8.39±0.07(H2O
t undefined
I = 0.30
(NaCl)) (Uncertain) |
| Hazard Information | Back Directory | [Uses]
Thenalidine is an antihistamine that has anticholinergic properties which is used as an antipruritic drugs. | [Definition]
ChEBI: Thenalidine is a dialkylarylamine and a tertiary amino compound. | [Brand name]
Sanbosten. | [World Health Organization (WHO)]
Thenalidine, a piperidine antihistamine, was introduced in 1953
for the management of dermatologic and allergic conditions. By 1958 its use had
been associated with cases of severe neutropenia, two of them fatal, which led to
its withdrawal in the United States of America and subsequently in the United
Kingdom. Over the next fifteen years, continued reports of its association with
cases of neutropenia resulted in further withdrawals in many countries. It is
apparently still available, however, in some combination products. | [Synthesis]
Thenalidine is synthesized by
alkylation of 1-methyl-4-phenylaminopiperidine
with 2-chloromethyl thiophene . |
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