| Identification | Back Directory | [Name]
L 888607 | [CAS]
860033-06-3 | [Synonyms]
L 888607
1H-Pyrrolo[1,2-a]indole-1-acetic acid, 9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-, (1S)- | [Molecular Formula]
C19H15ClFNO2S | [MDL Number]
MFCD31692362 | [MOL File]
860033-06-3.mol | [Molecular Weight]
375.84 |
| Chemical Properties | Back Directory | [Boiling point ]
583.8±50.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 150 mg/mL (399.11 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
4.53±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite[1]. | [in vivo]
L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo[1]. | Animal Model: | Male (ICR)BR mice[1] | | Dosage: | 5 mg/kg, 20 mg/kg | | Administration: | i.v., 5 mg/kg, single or oral, 20 mg/kg, single | | Result: | Showed no obvious side effect. |
| [IC 50]
DP: 0.8 nM (Ki); TP Receptor: 283 nM (Ki); FP Receptor: 10018 nM (Ki); IP Receptor: 14434 nM (Ki) | [References]
[1] Gervais FG, Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol Pharmacol. 2005 Jun;67(6):1834-9. DOI:10.1124/mol.104.009068 |
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MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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