| Identification | Back Directory | [Name]
Amphimedine | [CAS]
86047-14-5 | [Synonyms]
Amphimedine
8H-Benzo[b]pyrido[4,3,2-de][1,8]phenanthroline-8,11(10H)-dione, 10-methyl- | [Molecular Formula]
C19H11N3O2 | [MOL File]
86047-14-5.mol | [Molecular Weight]
313.31 |
| Chemical Properties | Back Directory | [Melting point ]
>340 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
644.3±55.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [pka]
0.60±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine. | [References]
[1] Deoxyamphimedine, a New Pyridoacridine Alkaloid from Two Tropical Xestospongia Sponges |
|
|