| Identification | Back Directory | [Name]
5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER | [CAS]
860624-89-1 | [Synonyms]
Methyl 5-bromoindole-7-carboxylate
methyl 5-bromo-1H-indole-7-carboxylate
5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER
5-BroMo-1H-indol-7-carboxylic acid Methyl ester
5-Bromo-1H-indole-7-carboxylic acid methyl ester
1H-Indole-7-carboxylic acid, 5-bromo-, methyl ester
5-bromo-1H-Indole-7-carboxylic acid methyl ester (9CI ACI)
1H-Indole-7-carboxylic acid, 5-bromo-, methyl ester (9CI, ACI) | [Molecular Formula]
C10H8BrNO2 | [MDL Number]
MFCD08062511 | [MOL File]
860624-89-1.mol | [Molecular Weight]
254.08 |
| Chemical Properties | Back Directory | [Boiling point ]
382.6±22.0 °C(Predicted) | [density ]
1.629±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.46±0.30(Predicted) | [Appearance]
Light yellow to brown Solid | [CAS DataBase Reference]
860624-89-1 |
| Hazard Information | Back Directory | [Synthesis]
Iodomethane (7.81 mL, 125 mmol) was slowly added dropwise to a solution of N,N-dimethylformamide (50 mL) containing 5-bromo-1H-indole-7-carboxylic acid (10 g, 41.7 mmol) and sodium carbonate (17.66 g, 167 mmol). The reaction mixture was stirred continuously for 2 h at room temperature. Upon completion of the reaction, it was filtered through a silica gel pad (500 g) and eluted with ether (600 mL). The collected eluate was washed once with deionized water (100 mL) and subsequently concentrated under reduced pressure to afford methyl 5-bromoindole-7-carboxylate (9.65 g, 91% yield). The product was confirmed by LC/MS analysis: m/z 253.8 (M+), retention time 2.15 min. | [References]
[1] Patent: WO2008/118724, 2008, A1. Location in patent: Page/Page column 69-70
[2] ACS Medicinal Chemistry Letters, 2018, |
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| Company Name: |
Heterochem
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| Tel: |
027-88041443 13072715837 |
| Website: |
www.hetero-chem.com |
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