| Identification | Back Directory | [Name]
BMY 25368 | [CAS]
86134-80-7 | [Synonyms]
BMY 25368
3-Amino-4-[3-(3-piperidinomethylphenoxy)propylamino]-3-cyclobutene-1,2-dione
3-Cyclobutene-1,2-dione, 3-amino-4-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]- | [Molecular Formula]
C19H25N3O3 | [MOL File]
86134-80-7.mol | [Molecular Weight]
343.42 |
| Hazard Information | Back Directory | [Uses]
BMY-25368 (SKF 94482) is a histamine H2 receptor antagonist that acts as a gastric acid secretion inhibitor. BMY-25368 competitively antagonizes gastric secretion stimulated by histamine and also antagonizes gastric secretion stimulated by Pentagastrin (HY-A0261), Bethanechol (HY-B0406), and food[1]. | [References]
[1] Cavanagh RL, et al. Effect of BMY-25368, a potent and long-acting histamine H2-receptor antagonist, on gastric secretion and aspirin-induced gastric lesions in the dog. Aliment Pharmacol Ther. 1989 Jun;3(3):299-313. DOI:10.1111/j.1365-2036.1989.tb00217.x |
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