| Identification | Back Directory | [Name]
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL | [CAS]
86215-36-3 | [Synonyms]
CL216303
CL-216303
CL 216303
CL-216303 HCl
DOV216303 HCl
CL216303 HCl,CL 216303 HCl
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride | [Molecular Formula]
C11H12Cl3N | [MDL Number]
MFCD06407666 | [MOL File]
86215-36-3.mol | [Molecular Weight]
264.58 |
| Hazard Information | Back Directory | [Uses]
DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3]. | [Biological Activity]
Triple reuptake inhibitor (TRI); serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI); IC50 values of ~2014and 78 nMrespectively. | [References]
[1] Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. DOI:10.1111/j.1527-3458.2006.00123.x
[2] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[3] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561 |
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