| Identification | Back Directory | [Name]
CAY10576 | [CAS]
862812-98-4 | [Synonyms]
CAY10576
IKK-3 Inhibitor
5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
2-Thiophenecarbonitrile, 5-(5,6-diMethoxy-1H-benziMidazol-1-yl)-3-[[2-(Methylsulfonyl)phenyl]Methoxy]- | [Molecular Formula]
C22H19N3O5S2 | [MDL Number]
MFCD10567700 | [MOL File]
862812-98-4.mol | [Molecular Weight]
469.53 |
| Chemical Properties | Back Directory | [Boiling point ]
744.4±70.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 45 mg/mL (95.84 mM; Need ultrasonic) | [form ]
Powder | [pka]
3.09±0.10(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3 | [InChIKey]
LDTAHRLHGHFHKP-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
GSK 319347A is a potent and selective IKKε kinase inhibitor. | [Definition]
ChEBI: 5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile is a member of benzimidazoles. | [Biological Activity]
Cell permeable: no''Primary Target
IKK-3''Product competes with ATP.''Reversible: no''Target IC50: 40 nM against IKK-3 (IKK-ε) | [IC 50]
TBK1: 93 nM (IC50); IKK-ε: 469 nM (IC50); IKK2: 790 nM (IC50) | [storage]
Store at -20°C |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Musechem
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+1-800-259-7612 |
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www.musechem.com |
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cjbscvictory
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amyjet
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InvivoChem
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https://www.invivochem.cn/ |
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