| Identification | Back Directory | [Name]
6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one, 10-methoxy- | [CAS]
86293-40-5 | [Synonyms]
6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one, 10-methoxy- | [Molecular Formula]
C15H10N2O2 | [MOL File]
86293-40-5.mol | [Molecular Weight]
250.25 |
| Chemical Properties | Back Directory | [Melting point ]
203-205 °C(Solv: dichloromethane (75-09-2)) | [Boiling point ]
384.1±42.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.14±0.20(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Description]
Methylaervine is a natural antifungal agent, significantly inducing lipid peroxidation, activating the antioxidant enzymes, and exhibiting effective activity against F. solani (EC50 = 10.56 μM). | [Uses]
0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research[1]. | [References]
[1] Torquato HFV, et al. DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G2/M and Myeloid Differentiation of Acute Myeloid Leukemias and Leukemic Stem Cells. ACS Omega. 2024 Aug 22;9(35):37343-37354. DOI:10.1021/acsomega.4c05435 |
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| Company Name: |
Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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