| Identification | Back Directory | [Name]
CP 59430 | [CAS]
86329-06-8 | [Synonyms]
CP 59430
2-[4-(4-Azidobenzoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline | [Molecular Formula]
C21H22N8O3 | [MOL File]
86329-06-8.mol | [Molecular Weight]
434.46 |
| Hazard Information | Back Directory | [Description]
CP 59430 is an azide analog of prazosin, a highly selective alpha 1-adrenergic receptor antagonist. | [Uses]
CP59430 is an azide analog of the α-adrenaline receptor antagonist Prazosin (HY-B0193). P59430 behaves as a competitive antagonist of α1-adrenaline receptor before photolysis. After photolysis, it specifically and irreversibly labels α1-adrenaline receptor and exhibits non-competitive antagonist activity. CP59430 can be used for the study of receptor molecular characterization[1]. | [References]
[1] Hess, et al. "Photoaffinity label for the alpha 1-adrenergic receptor: synthesis and effects on membrane and affinity-purified receptors." Proceedings of the National Academy of Sciences 80.8 (1983): 2102-2106. DOI:10.1073/pnas.80.8.2102 |
|
|