| Identification | Back Directory | [Name]
5,8-epidioxyergosta-6,9(11),22-trien-3-ol | [CAS]
86363-50-0 | [Synonyms]
22-trien-3-ol
8-Epidioxyergosta-6
9,11-Dehydroergosterol peroxide
5,8-epidioxyergosta-6,9(11),22-trien-3-ol
Ergosta-6,9(11),22-trien-3-ol, 5,8-epidioxy-, (3β,5α,8α,22E)- | [Molecular Formula]
C28H42O3 | [MOL File]
86363-50-0.mol | [Molecular Weight]
426.64 |
| Chemical Properties | Back Directory | [Boiling point ]
512.7±50.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
14.82±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis[1][2]. | [target]
PARP | Bcl-2/Bax | Caspase | ERK | Akt | CDK | p21 | P450 (e.g. CYP17) | [IC 50]
Microbial Metabolite | [References]
[1] Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H. 5alpha,8alpha-Epidioxy-22E-ergosta-6,9(11),22-trien-3beta-ol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull. 2006;29(4):755-759. DOI:10.1248/bpb.29.755
[2] Zheng L, et al. Apoptosis induced by 9,11 dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl 1 dependent. Mol Med Rep. 2018;18(1):938-944. DOI:10.3892/mmr.2018.9035 |
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