| Identification | Back Directory | [Name]
MMAF-OMe | [CAS]
863971-12-4 | [Synonyms]
MMAF-OMe
MONOMETHYL AURISTATIN F METHYL ESTER
ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin
L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester | [Molecular Formula]
C40H67N5O8 | [MDL Number]
MFCD30535529 | [MOL File]
863971-12-4.mol | [Molecular Weight]
746 |
| Chemical Properties | Back Directory | [Boiling point ]
871.8±65.0 °C(Predicted) | [density ]
1.095±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.89±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. | [IC 50]
Auristatin | [References]
[1] Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300 DOI:10.1158/1535-7163.MCT-15-0881 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|