| Identification | Back Directory | [Name]
OPIORPHIN | [CAS]
864084-88-8 | [Synonyms]
OPIORPHIN
opiorphin H-6504
H-Gln-Arg-Phe-Ser-Arg-OH
L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine
L-Arginine,L-glutaminyl-L-arginyl-L-phenylalanyl-L-seryl- | [Molecular Formula]
C29H48N12O8 | [MDL Number]
MFCD09752700 | [MOL File]
864084-88-8.mol | [Molecular Weight]
692.77 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [pka]
3.23±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
Opiorphin degrades enkephalin by inhibiting neutral endopeptidase and aminopeptidase N. Induces anorexic effect. | [Definition]
ChEBI: Opiorphin is an oligopeptide. | [in vivo]
Opiorphin (1.25-10 μg/kg; ICV; 0-60 min; male Kunming mice) induces potent analgesic effect in a dose- and time-dependent manner (ED50=3.22 μg/kg)[1]. | Animal Model: | Male Kunming mice[1] | | Dosage: | 1.25, 2.5, 5, 10 μg/kg | | Administration: | Intracerebroventrical injection; post-drug latency measurements were performed at 5, 10, 20, 30, 40, 50 and 60 min | | Result: | Had the percentage change of tail withdrawal latency (TWL) at 10 min after i.c.v. administration of 1.25-10 mg/kg was 28.90%, 44.37%, 56.43% and 91.899.79%, respectively. |
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