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864420-54-2

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864420-54-2 Structure

864420-54-2 Structure
IdentificationBack Directory
[Name]

NEDD8 inhibitor M22
[CAS]

864420-54-2
[Synonyms]

NAE-IN-M22
NEDD8 inhibitor M22
4-Piperidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-
[Molecular Formula]

C20H24Cl2N2
[MDL Number]

MFCD01453465
[MOL File]

864420-54-2.mol
[Molecular Weight]

363.32
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 250 mg/mL (688.10 mM)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo[1].
[in vivo]

M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts[1].
M22 (0.36-90 μM) has low acute toxicity in zebrafish model[1].

[References]

[1] Lu P, et, al. Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening. ACS Chem Biol. 2016 Jul 15;11(7):1901-7. DOI:10.1021/acschembio.6b00159
Spectrum DetailBack Directory
[Spectrum Detail]

NEDD8 inhibitor M22(864420-54-2)1HNMR
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