| Identification | Back Directory | [Name]
NAP1051 | [CAS]
864516-77-8 | [Synonyms]
NAP1051
7-Octenoic acid, 5,6-dihydroxy-8-[3-[(1E,3R)-3-hydroxy-1-octen-1-yl]phenyl]-, methyl ester, (5S,6R,7E)- | [Molecular Formula]
C23H34O5 | [MOL File]
864516-77-8.mol | [Molecular Weight]
390.51 |
| Chemical Properties | Back Directory | [Boiling point ]
573.553±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.115±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
13.450±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
NAP1051 is a biomimetic analog of lipin A4 that achieves anti-tumor effects by targeting the inflammatory tumor microenvironment. NAP1051 inhibits neutrophil chemotaxis to fMLP and stimulates macrophage efferocytosis by activating AKT. NAP1051 can be used in colorectal cancer research[1]. | [References]
[1] Tiange Dong, et al. "NAP1051, a lipoxin A4 biomimetic analogue, demonstrates antitumor activity against the tumor microenvironment." Molecular Cancer Therapeutics 20.12 (2021): 2384-2397. DOI:10.1158/1535-7163.MCT-21-0414 |
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