| Identification | Back Directory | [Name]
ethyl (2-(5-nitrothiophene-2-carboxamido)thiophene-3-carbonyl)carbamate | [CAS]
864941-31-1 | [Synonyms]
EACC
ethyl (2-(5-nitrothiophene-2-carboxamido)thiophene-3-carbonyl)carbamate
Carbamic acid, [[2-[[(5-nitro-2-thienyl)carbonyl]amino]-3-thienyl]carbonyl]-, ethyl ester (9CI) | [Molecular Formula]
C13H11N3O6S2 | [MOL File]
864941-31-1.mol | [Molecular Weight]
369.37 |
| Chemical Properties | Back Directory | [density ]
1.565±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 16.88 mg/mL (45.70 mM) | [form ]
Solid | [pka]
10.36±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1]. | [storage]
Store at -20°C | [References]
[1] Vats S, et al. A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes. Mol Biol Cell. 2019 Aug 1;30(17):2283-2295. DOI:10.1091/mbc.E18-08-0482 |
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