| Identification | Back Directory | [Name]
MK-0668 | [CAS]
865110-07-2 | [Synonyms]
MK-0668
USYYNLPEWBGIMJ-ICTDUYRTSA-N
(4r)-1-[(3-Cyanophenyl)Sulfonyl]-4- (Cyclobutylamino)-L-Prolyl-4-[[(3,5-Dichloro-4-Pyridinyl)Carbonyl]Amino]-L-Phenylalanine
L-Phenylalanine, (4R)-1-[(3-cyanophenyl)sulfonyl]-4-(cyclobutylaMino)-L-prolyl-4-[[(3,5-dichloro-4-pyridinyl)carbonyl]aMino]- | [Molecular Formula]
C31H30Cl2N6O6S | [MDL Number]
MFCD18782636 | [MOL File]
865110-07-2.mol | [Molecular Weight]
685.58 |
| Hazard Information | Back Directory | [Uses]
MK-0668 is an amino acid-based, potent antagonist of unactivated VLA-4, with an IC50) of 0.13 nM in human whole blood. And MK-0668 exhibits IC50s of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats[1]. | [References]
[1] Discovery of N-{N-[(3-Cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(l)-prolyl}-4-[(3′,5′-dichloroisonicotinoyl)amino]-(l)-phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4
J. Med. Chem., 2009, 52 (11), pp 3449-3452 |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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