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865317-30-2

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865317-30-2 Structure

865317-30-2 Structure
IdentificationBack Directory
[Name]

CDK5 inhibitor 20-223 (CP 668863)
[CAS]

865317-30-2
[Synonyms]

CDK5 inhibitor 20-223
CDK5 inhibitor 20-223 (CP 668863)
2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-
[Molecular Formula]

C19H19N3O
[MDL Number]

MFCD32857141
[MOL File]

865317-30-2.mol
[Molecular Weight]

305.37
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent[1].
[in vivo]

CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice[1].

Animal Model:Athymic nude mice[1]
Dosage:8 mg/kg
Administration:Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections.
Result:Reduced tumor growth and tumor weight in vivo.
[IC 50]

CDK2: 6.0 nM (IC50); CDK5: 8.8 nM (IC50)
[storage]

Store at -20°C
[References]

[1] Caroline M Robb, et al. Characterization of CDK(5) Inhibitor, 20-223 (Aka CP668863) for Colorectal Cancer Therapy. Oncotarget. 2017 Dec 28;9(4):5216-5232. DOI:10.18632/oncotarget.23749
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