| Identification | Back Directory | [Name]
ON-013100 | [CAS]
865783-95-5 | [Synonyms]
ON-013100
UNII-J3I19I491A
ON-013100;ON 013100;ON013100
CDK,ON-013100,ON 013100,inhibit,Inhibitor,Cyclin dependent kinase,ON013100
Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]- | [Molecular Formula]
C19H22O7S | [MDL Number]
MFCD31540462 | [MOL File]
865783-95-5.mol | [Molecular Weight]
394.44 |
| Hazard Information | Back Directory | [Uses]
ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression. | [IC 50]
Cdk4/cyclin D1 | [References]
[1] Cho SY, et al. Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal. 2013 Mar 5;75:138-44. DOI:10.1016/j.jpba.2012.11.022
[2] Park IW, et al. Evaluation of novel cell cycle inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. DOI:10.1038/sj.onc.1210350
[3] Neel Jasani, et al. Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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