| Identification | Back Directory | [Name]
Acetamide, 2-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-N-[(5S,5aS,8aR,9R)-5,5a,6,8,8a,9-hexahydro-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-5-yl]- | [CAS]
866874-63-7 | [Synonyms]
F-14512 (free base)
F 14512 (free base),F14512 (free base)
Acetamide, 2-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-N-[(5S,5aS,8aR,9R)-5,5a,6,8,8a,9-hexahydro-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-5-yl]- | [Molecular Formula]
C33H47N5O8 | [MOL File]
866874-63-7.mol | [Molecular Weight]
641.76 |
| Chemical Properties | Back Directory | [Boiling point ]
863.5±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.94±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
F-14512 is a targeted cytotoxic compound that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 combines an epipodophyllotoxin core that targets topoisomerase II with a spermine group that acts as a cell delivery vehicle, with improved selectivity for tumor cells. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and demonstrates high potency in multiple human cell lines (median IC50=0.18 μM). In the MX1 breast tumor xenograft model, F-14512 exhibits potent antitumor activity[1]. | [References]
[1] F-14512, a Potent Antitumor Agent Targeting Topoisomerase II Vectored into Cancer Cells via the Polyamine Transport System |
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