| Identification | Back Directory | [Name]
5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL | [CAS]
867012-70-2 | [Synonyms]
3-Amino-6-methoxy-5-methyL
5-AMINO-2-METHOXY-3-PICOLINE HCL
6-methoxy-5-methylpyridin-3-amine
6-Methoxy-5-methyl-3-pyridinamine
2-methoxy-3-methyl-5-aminopyridine
3-Amino-6-methoxy-5-methylpyridine
3-Pyridinamine, 6-methoxy-5-methyl-
5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL
3-Amino-6-methoxy-5-methylpyridine 97%
5-AMINO-2-METHOXY-3-PICOLINE HYDROCHLORIDE
5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL ISO 9001：2015 REACH
6-Methoxy-5-me6-Methoxy-5-methylpyridin-3-aminethylpyridin-3-amine | [Molecular Formula]
C7H10N2O | [MDL Number]
MFCD05662388 | [MOL File]
867012-70-2.mol | [Molecular Weight]
138.17 |
| Chemical Properties | Back Directory | [Melting point ]
53-57°C | [Boiling point ]
268℃ | [density ]
1.103 | [Fp ]
116℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
4.62±0.20(Predicted) | [Appearance]
Pale purple to purple Powder |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-amino-6-methoxy-5-methylpyridine from 2-methoxy-5-nitro-3-methylpyridine: (1c) 6-methoxy-5-methyl-3-pyridinamine [Eq. 10]; 2-methoxy-3-methyl-5-nitro-pyridine (1.63 g, 9.71 mmol) was dissolved in methanol (50 mL), 10% Pd/C catalyst was added (50% water content, 800 mg) and the reaction was stirred under hydrogen atmosphere for 2 h 10 min. Upon completion of the reaction, it was filtered through diatomaceous earth and the solvent was evaporated to afford 3-amino-6-methoxy-5-methylpyridine (1.25 g, 9.0 mmol, 93% yield) as a blue oil.1H NMR (400 MHz, DMSO-d6) δ ppm: 2.03 (3H, s), 3.73 (3H, s), 4.62 (2H, s), and 6.83-6.86 (1H, m), 7.31-7.34 (1H, m). | [References]
[1] Patent: WO2005/103049, 2005, A1. Location in patent: Page/Page column 63-64
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3056 - 3062 |
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