| Identification | Back Directory | [Name]
Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro- | [CAS]
867301-81-3 | [Synonyms]
WAY-659694
Anti-inflammatory agent 34
N-(4-Methyl-2-oxo-2H-chromen-7-yl)-4-nitrobenzamide
Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro- | [Molecular Formula]
C17H12N2O5 | [MOL File]
867301-81-3.mol | [Molecular Weight]
324.29 |
| Chemical Properties | Back Directory | [Melting point ]
>320 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
470.4±45.0 °C(Predicted) | [density ]
1.436±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF : 1.85 mg/mL (5.70 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
11.05±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory agent 34 (Compound IVf) is an orally active anti-inflammatory and analgesic agent[1]. | [in vivo]
Anti-inflammatory agent 34 (Compound IVf) (200mg/kg; p.o.; single dose) shows inhibitory activity on carrageenan induced rat paw edema, and shows analgesic activity in mice[1]. | Animal Model: | Male albino rats, carrageenan-induced rat paw edema assay model[1] | | Dosage: | 200 mg/kg | | Administration: | Oral, single dose | | Result: | Showed 55.7 ± 0.019% inhibition on carrageenan induced rat paw edema at the 3rd h. |
| Animal Model: | Albino mice, acetic acid induced writhing method[1] | | Dosage: | 200 mg/kg | | Administration: | Oral, single dose | | Result: | Showed 48.1% analgesic activity. |
| [References]
[1] Ronad PM, et al. Synthesis and evaluation of anti-inflammatory and analgesic activities of a novel series of substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides. Arzneimittelforschung. 2008;58(12):641-6. DOI:10.1055/s-0031-1296565 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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