| Identification | Back Directory | [Name]
1H-Indole, 2,2'-(1,4-phenylene)bis[6-(4,5-dihydro-1H-imidazol-2-yl)- | [CAS]
868971-24-8 | [Synonyms]
MBX 1066
1H-Indole, 2,2'-(1,4-phenylene)bis[6-(4,5-dihydro-1H-imidazol-2-yl)- | [Molecular Formula]
C28H24N6 | [MOL File]
868971-24-8.mol | [Molecular Weight]
444.53 |
| Hazard Information | Back Directory | [Uses]
MBX 1066 is a potent antibacterial agent. MBX 1066 shows inhibition for Mycobacterium tuberculosis. MBX 1066 shows antibacterial activity in mice[1]. | [in vivo]
MBX 1066 (1, 10 mg/kg; i.v.; single dose, one hour post infection) shows antibacterial activity and increases the mice survival[1]. | Animal Model: | ICR/Swiss Webster mice (Staphylococcus aureus strain NRS384) [1] | | Dosage: | 1, 10 mg/kg | | Administration: | I.v.; single dose, one hour post infection | | Result: | Increased the survival in a dose-dependent maner. |
| [References]
[1] Panchal RG, et al. Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis. J Antibiot (Tokyo). 2013 Jan;66(1):47-9. DOI:10.1038/ja.2012.93 |
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