| Identification | Back Directory | [Name]
FINO2 | [CAS]
869298-31-7 | [Synonyms]
FINO2
1,2-Dioxaspiro[4.5]decane-3-ethanol, 8-(1,1-dimethylethyl)-3-methyl-, (5α,8α)- | [Molecular Formula]
C15H28O3 | [MOL File]
869298-31-7.mol | [Molecular Weight]
256.39 |
| Chemical Properties | Back Directory | [Boiling point ]
323.8±11.0 °C(Predicted) | [density ]
1.02±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml | [form ]
A solid | [pka]
14.90±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1]. | [Definition]
ChEBI: FINO2 is an oxaspiro compound that is 1,2-dioxaspiro[4.5]decane substituted by methyl, 2-hydroxyethyl and tert-butyl groups at positions 3, 3 and 8, respectivey (the 5s,8s-stereoisomer). It induces ferroptosis in cancer cells by indirectly inhibiting glutathione peroxidase 4 (GPX4) enzymatic function and directly oxidizes iron leading to widespread lipid peroxidation. It has a role as a ferroptosis inducer and an antineoplastic agent. It is an oxaspiro compound, an organic peroxide, a primary alcohol and an organic heterobicyclic compound. | [References]
[1] Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515. DOI:10.1038/s41589-018-0031-6 |
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