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869497-75-6

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869497-75-6 Structure

869497-75-6 Structure
IdentificationBack Directory
[Name]

1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
[CAS]

869497-75-6
[Synonyms]

VUF 6002
VUF6002 maleate
VUF 6002 maleate
JNJ 10191584 MALEATE
JNJ 10191584 maleate salt
1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
[Molecular Formula]

C17H19ClN4O5
[MDL Number]

MFCD08703121
[MOL File]

869497-75-6.mol
[Molecular Weight]

394.81
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at RT
[solubility ]

DMSO: ≥10mg/mL
[form ]

powder
[color ]

off-white to light tan
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-36/37/38
[Safety Statements ]

26
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

A highly selective histamine H4 receptor silent antagonist
[Biological Activity]

Highly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM) and is > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). In vitro, inhibits mast cell and eosinophil chemotaxis with IC 50 values of 138 and 530 nM respectively. Orally active in vivo .
[storage]

room temperature (desiccate)
Spectrum DetailBack Directory
[Spectrum Detail]

1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE(869497-75-6)1HNMR
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