| Identification | Back Directory | [Name]
Boc-Val-Cit-PABA | [CAS]
870487-09-5 | [Synonyms]
Boc-Val-Cit-PABA
Boc-Val-Cit-PAB-OH
Boc-Gly-Gly-Phe-Gly
(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide
N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | [Molecular Formula]
C23H37N5O6 | [MDL Number]
MFCD22381208 | [MOL File]
870487-09-5.mol | [Molecular Weight]
479.57 |
| Chemical Properties | Back Directory | [Boiling point ]
771.3±60.0 °C(Predicted) | [density ]
1.209±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 100 mg/mL (208.52 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.25±0.46(Predicted) | [color ]
White to off-white | [InChIKey]
NTAKMIJAGHASRI-ROUUACIJSA-N | [SMILES]
C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O)C1=CC=C(CO)C=C1 |
| Hazard Information | Back Directory | [Description]
Boc-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit peptide will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition. | [Uses]
Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Protease Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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