| Identification | Back Directory | [Name]
(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol | [CAS]
870640-62-3 | [Synonyms]
(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol | [Molecular Formula]
C14H23NO | [MDL Number]
MFCD28385888 | [MOL File]
870640-62-3.mol | [Molecular Weight]
221.34 |
| Chemical Properties | Back Directory | [Boiling point ]
313.6±17.0 °C(Predicted) | [density ]
0.975±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
14.71±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Monomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. | [References]
[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931 |
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