| Identification | Back Directory | [Name]
CXCR3 Antagonist 6c | [CAS]
870998-13-3 | [Synonyms]
CXCR3 Antagonist 6c
CXCR3 Antagonist 6c,CXCR-3 Antagonist 6c
1H-1,4-Diazepine-1-carboxamide, 4-[2-[(3-chlorobenzoyl)amino]-4-[[[2-(2,4-dichlorophenyl)ethyl]amino]carbonyl]phenyl]-N-ethylhexahydro- | [Molecular Formula]
C30H32Cl3N5O3 | [MDL Number]
MFCD22123246 | [MOL File]
870998-13-3.mol | [Molecular Weight]
616.97 |
| Chemical Properties | Back Directory | [Boiling point ]
768.6±60.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: >100mM | [form ]
A crystalline solid | [pka]
12.42±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CXCR3 antagonist 1 (compound 6c) is a selective and non-cytotoxic CXCR3 antagonist (IC50=0.06 μM). CXCR3 antagonist 1 has potential in researching inflammatory diseases (including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes)[1]. | [IC 50]
CXCR3: 0.06 μM (IC50) | [References]
[1] Cole A G, et al. Identification and initial evaluation of 4-N-aryl-[1, 4] diazepane ureas as potent CXCR3 antagonists. Bioorganic Med. Chem Lett. 2006 Jan;16(1):200-203. |
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