| Identification | Back Directory | [Name]
DRAK2-IN-16 | [CAS]
871837-60-4 | [Synonyms]
DRAK2-IN-1
DRAK2-IN-16
DRAK2IN1,DRAK2 IN 1,DRAK-2-IN-1
Pentanamide, N-[3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-2,3-dihydro-2-oxo-1H-indol-5-yl]- | [Molecular Formula]
C21H20N4O3 | [MDL Number]
MFCD32215315 | [MOL File]
871837-60-4.mol | [Molecular Weight]
376.41 |
| Chemical Properties | Back Directory | [Boiling point ]
668.4±55.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (332.08 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.57±0.20(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
DRAK2-IN-1, compound 16, is a potent, selective and ATP-competitive DRAK2 inhibitor with IC50and Kivalues of 3 nM and 0.26 nM, respectively.
DRAK2-IN-1 also has inbitory effect on DRAK1 (IC50=51 nM)[1]. | [storage]
Store at -20°C | [References]
[1] Jung ME, et al.Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.Bioorg Med Chem Lett.?2016 Jun 1;26(11):2719-23 DOI:10.1016/j.bmcl.2016.03.111 |
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