| Identification | Back Directory | [Name]
GW 610 | [CAS]
872726-44-8 | [Synonyms]
GW 610
NSC 721648
NSC 721648 PMX 610
NSC 721648 - CAS 872726-44-8 - Calbiochem | [Molecular Formula]
C15H12FNO2S | [MDL Number]
MFCD12024619 | [MOL File]
872726-44-8.mol | [Molecular Weight]
289.325 |
| Chemical Properties | Back Directory | [Melting point ]
110 °C | [Boiling point ]
422.8±55.0 °C(Predicted) | [density ]
1.293±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMF:10.0(Max Conc. mg/mL);34.56(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:9.5(Max Conc. mg/mL);32.84(Max Conc. mM) | [form ]
White crystalline solid | [pka]
0.73±0.10(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed. Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity. | [Uses]
GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity. | [References]
[1] CATRIONA G. MORTIMER. Antitumor Benzothiazoles. 26.1 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory Activity against Lung, Colon, and Breast Cancer Cell Lines[J]. Journal of Medicinal Chemistry, 2005, 49 1: 179-185. DOI: 10.1021/jm050942k |
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