| Chemical Properties | Back Directory | [Melting point ]
63-64 °C | [density ]
0.963±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
12.25±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA2 with a XI(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy[1]. | [in vivo]
AX048 (0-30 mg/kg, i.p.) reduces the thermal hyperalgesia with the ED50 of 1.2 mg/kg in Sprague Dawle rats[1]. | Animal Model: | Carrageenan-induced thermal hyperalgesia in Sprague Dawley rats[1] | | Dosage: | 0-30 mg/kg | | Administration: | i.p. | | Result: | Reduced the escape latencies in a dose-dependent manner. |
| [IC 50]
cPLA2 | [References]
[1] Yaksh TL, et al., Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan;316(1):466-75. DOI:10.1124/jpet.105.091686 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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