| Identification | Back Directory | [Name]
4-Piperidinol, 4-(4-bromophenyl)-1-[(5-methoxy-1H-indol-3-yl)methyl]- | [CAS]
873445-60-4 | [Synonyms]
SV-156
4-Piperidinol, 4-(4-bromophenyl)-1-[(5-methoxy-1H-indol-3-yl)methyl]- | [Molecular Formula]
C21H23BrN2O2 | [MOL File]
873445-60-4.mol | [Molecular Weight]
415.32 |
| Hazard Information | Back Directory | [Description]
SV-156 is a highly selective dopamine receptor 2 (D2) antagonist. | [Uses]
SV 156 is a potent and selective D2 dopamine receptor antagonist, with a Ki of 2.5 nM for hD2. SV 156 has approximately 40-fold binding selectivity for D2 dopamine receptors compared to the D3 receptor subtype. SV 156 can be used for L-DOPA (HY-N0304)-associated abnormal involuntary movements (AIMs) research[1]. | [IC 50]
Human D2 Receptor: 2.5 ± 0.4 nM (Ki); Human D3 Receptor: 96.9 ± 4.3 nM (Ki); Human D4 Receptor: 700 ± 56 nM (Ki) | [References]
[1] Kumar R, et al. Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats. Neuropharmacology. 2009 May-Jun;56(6-7):956-69. DOI:10.1016/j.neuropharm.2009.01.019 |
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