| Identification | Back Directory | [Name]
T-2307 | [CAS]
873546-31-7 | [Synonyms]
T-2307
Benzenecarboximidamide, 4,4'-[1,4-piperidinediylbis(3,1-propanediyloxy)]bis- | [Molecular Formula]
C25H35N5O2 | [MDL Number]
MFCD32640691 | [MOL File]
873546-31-7.mol | [Molecular Weight]
437.58 |
| Chemical Properties | Back Directory | [Boiling point ]
616.3±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (114.26 mM; ultrasonic and adjust pH to 3 with HCl) | [form ]
Solid | [pka]
12.50±0.50(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) [1]. | [in vivo]
In mouse models of disseminated candidiasis, cryptococcosis, and aspergillosis, the ED50 of T-2307 were 0.00755, 0.117, and 0.391 mg/kg, respectively[1]. | Animal Model: | 4-week-old specific-pathogen-free ICR strain male mice bearing systemic infections with?Candida albicans, Cryptococcus neoformans, and?Aspergillus fumigatus[1]. | | Dosage: | 0.001, 0.1, 1 mg/kg | | Administration: | Subcutaneously administered; once a day for 7 days, beginning at 2 h after the infection. | | Result: | In the systemic infection caused by?Candida albicans, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 0.01 mg/kg?compared with that in the control mice. The calculated ED50s of T-2307were 0.00755 mg/kg.
In the systemic infection caused by?Cryptococcus neoformans, all the control mice died by day 9. Mortality was significantly delayed in mice administered T-2307 at a dose of 0.1 mg/kg?compared with that in the control mice. The calculated ED50s of T-2307 were 0.117 mg/kg.
In the systemic infection caused by?Aspergillus fumigatus, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 1 mg/kg compared with that in the control mice. The calculated ED50s of T-2307 were 0.391 mg/kg. |
| [storage]
Store at -20°C | [References]
[1] Junichi Mitsuyama, et al. ?In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. Antimicrob Agents Chemother.?2008 Apr;52(4):1318-24. DOI:10.1128/AAC.01159-07
[2] Eio Yamada, et al. ?T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. Antimicrob Agents Chemother.?2010 Sep;54(9):3630-4. DOI:10.1128/AAC.00355-10 |
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