| Identification | Back Directory | [Name]
PHM-27 (HUMAN) | [CAS]
87403-73-4 | [Synonyms]
phm-27
PHI HUMAN
Human PHI
PHM, HUMAN
PHI-27, human
PHM-27 (HUMAN)
PHM-27 (PHI, human)
peptide histidine methionine
PEPTIDE HISTIDINE METHIONINE, HUMAN
HIS-ALA-ASP-GLY-VAL-PHE-THR-SER-ASP-PHE-SER-LYS-LEU-LEU-GLY-GLN-LEU-SER-ALA-LYS-LYS-TYR-LEU-GLU-SER-LEU-MET-NH2
H-HIS-ALA-ASP-GLY-VAL-PHE-THR-SER-ASP-PHE-SER-LYS-LEU-LEU-GLY-GLN-LEU-SER-ALA-LYS-LYS-TYR-LEU-GLU-SER-LEU-MET-NH2
L-Methioninamide, L-histidyl-L-alanyl-L-α-aspartylglycyl-L-valyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-phenylalanyl-L-seryl-L-lysyl-L-leucyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-α-glutamyl-L-seryl-L-leucyl- | [Molecular Formula]
C135H214N34O40S | [MDL Number]
MFCD00133766 | [MOL File]
87403-73-4.mol | [Molecular Weight]
2985.46 |
| Chemical Properties | Back Directory | [Boiling point ]
2732.1±65.0 °C(Predicted) | [density ]
1.303±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C
| [form ]
Solid | [color ]
White to off-white | [Sequence]
{His}{Ala}{Asp}{Gly}{Val}{Phe}{Thr}{Ser}{Asp}{Phe}{Ser}{Lys}{Leu}{Leu}{Gly}{Gln}{Leu}{Ser}{Ala}{Lys}{Lys}{Tyr}{Leu}{Glu}{Ser}{Leu}{Met}-NH2 |
| Hazard Information | Back Directory | [Uses]
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3]. | [References]
[1] N Itoh, et al. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature. 1983 Aug 11-17;304(5926):547-9. DOI:10.1038/304547a0
[2] Jian-Nong Ma, et al. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84. DOI:10.1016/j.bcp.2003.11.008
[3] I Kato, et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem. 1994 Aug 19;269(33):21223 PMID:8063743 |
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