| Identification | Back Directory | [Name]
m-PEG4-(CH2)3-acid | [CAS]
874208-84-1 | [Synonyms]
m-PEG4-CH2-acid
m-PEG4-(CH2)3-acid
tert-butyl 2,5,8,11-tetraoxapentadecan-15-oate | [Molecular Formula]
C11H22O6 | [MDL Number]
MFCD26498232 | [MOL File]
874208-84-1.mol | [Molecular Weight]
250.29 |
| Chemical Properties | Back Directory | [Boiling point ]
366.2±32.0 °C(Predicted) | [density ]
1.087±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
4.63±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
m-PEG4-(CH2)3-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG4-CH2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Zuluaga MF, et al. Enhanced prostate cancer targeting by modified protease sensitive photosensitizer prodrugs. Mol Pharm. 2012 Jun 4;9(6):1570-9. DOI:10.1021/mp2005774 |
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