| Hazard Information | Back Directory | [Description]
PPL-100, also known as PL-461 and PL-462, is a HIV protease inhibitor potentially for the treatment of HIV infection. | [Uses]
PPL-100 free acid is a potential agent for SERPINA1. PPL-100 free acid can be metabolically cleaved into PL-100 (HY-107468)[1][2]. | [References]
[1] Dandache S, et, al. PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63. DOI:10.1002/jmv.21329
[2] Qu T, et, al. Identification of potential biomarkers and drugs for papillary thyroid cancer based on gene expression profile analysis. Mol Med Rep. 2016 Dec;14(6):5041-5048. DOI:10.3892/mmr.2016.5855 |
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