| Identification | Back Directory | [Name]
3,5-DibroMo-1-Methylpyrazin-2(1H)-one | [CAS]
87486-34-8 | [Synonyms]
3,5-Dibromo-1-methylpyrazin-2(1H)
3,5-Dibromo-1-methylpyrazin-2-one
3,5-DibroMo-1-Methylpyrazin-2(1H)-one
2(1H)-Pyrazinone, 3,5-dibroMo-1-Methyl-
3,5-dibroMo-1-Methyl-1,2-dihydropyrazin-2-one | [Molecular Formula]
C5H4Br2N2O | [MDL Number]
MFCD12022617 | [MOL File]
87486-34-8.mol | [Molecular Weight]
267.906 |
| Chemical Properties | Back Directory | [Melting point ]
98 °C | [Boiling point ]
261.9±50.0 °C(Predicted) | [density ]
2.20±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
-6.54±0.70(Predicted) | [Appearance]
White to light brown Solid |
| Questions And Answer | Back Directory | [Uses]
3,5-Dibromo-1-methylpyrazine-2(1H)-one can be used as a pharmaceutical synthesis intermediate, such as in the preparation of 5-bromo-3-(4-(1,4-dimethyl-3-oxopirarin-2-yl)phenylamino)-1-methylpyrazine-2(1H)-one, which can be prepared by reacting 1,2-dichlorobenzene with oxalyl bromide. |
| Hazard Information | Back Directory | [Synthesis]
To a suspension of 2-methylaminoacetonitrile hydrochloride (20 g, 142.0 mmol) in dichloromethane (DCM, 1300 mL) was slowly added oxalyl bromide (54 mL, 188.67 mmol), followed by the dropwise addition of N,N-dimethylformamide (DMF, 1.5 mL) at 0 °C. The reaction mixture was warmed to 55 °C and stirred for 16 hours. Upon completion of the reaction, the dichloromethane was removed by distillation under reduced pressure and the crude product obtained was purified by column chromatography using 2% methanol/dichloromethane (MeOH/CH2Cl2) as eluent to afford the target compound 3,5-dibromo-1-methylpyrazin2(1H)-one as a light yellow solid (34 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.1 (s, 1H), 3.4 (s, 3H).LC-MS analysis showed the molecular ion peak m/z 268.9 ([M + 1]+). | [References]
[1] Patent: WO2014/108820, 2014, A1. Location in patent: Page/Page column 27
[2] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 23; 24 |
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