| Identification | Back Directory | [Name]
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE | [CAS]
874964-22-4 | [Synonyms]
(R)-Methyl pyrrolidine-3-...
(R)-methyl pyrrolidine-3-carboxylate
methyl(S)-pyrrolidine-3-carboxylatehydrochloride
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride
methyl (3R)-pyrrolidine-3-carboxylate hydrochloride
R-3-Pyrrolidinecarboxylic acid Methyl ester hydrochloride
(3R)-3-Pyrrolidinecarboxylic acid methyl ester hydrochloride
3-Pyrrolidinecarboxylic acid, Methyl ester, hydrochloride, (3R)-
3-Pyrrolidinecarboxylic acid, Methyl ester, hydrochloride (1:1), (3R)- | [Molecular Formula]
C6H12ClNO2 | [MDL Number]
MFCD11840195 | [MOL File]
874964-22-4.mol | [Molecular Weight]
165.62 |
| Hazard Information | Back Directory | [Uses]
(R)-Methyl Pyrrolidine-3-carboxylate Hydrochloride acts as a reagent for the synthesis of kinase inhibitor (ERK1/2). | [Synthesis]
To a stirred solution of (3R)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-pyrrolidinecarboxylic acid (1.03 g, 4.8 mmol) in methanol (25 mL) was added thionyl chloride (1 mL, 13.7 mmol) dropwise at room temperature under the protection of nitrogen atmosphere. The reaction mixture was heated to reflux for 2 hours and then cooled to room temperature. The reaction mixture was concentrated and the crude product was dissolved in dichloromethane. The solution was further concentrated to give 0.792 g (100% yield) of methyl (3R)-3-pyrrolidine carboxylic acid hydrochloride as an off-white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 9.93 (m, 2H), 3.74 (s, 3H), 3.58 (br s, 2H), 3.42 (br s, 2H), 3.26 (m, 1H), 2.36-2.25 (m, 2H). | [References]
[1] Patent: WO2009/5998, 2009, A1. Location in patent: Page/Page column 244 |
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