875629-26-8

50-00-0

36476-78-5

875629-26-8

General procedure for the synthesis of 1-methyl-3-azetidinecarboxylic acid from formaldehyde and 3-acridinecarboxylic acid: Example IX Synthesis of 1-methyl-azetidine-3-carboxylic acid 200 mg of azetidine-3-carboxylic acid was dissolved in 10 mL of methanol and 165 μL of 37% aqueous formaldehyde solution and 20 mg of 10% palladium carbon catalyst were added. The reaction mixture was hydrogenated at 50 °C. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation under vacuum to remove the solvent. The residue was redissolved in a solvent mixture of methanol and toluene and the solvent was again removed by evaporation under vacuum. The final product yield was 214 mg (94% yield, based on theoretical calculations). The product was analyzed by mass spectrometry (ESI+) and showed m/z = 116 [M + H]+.