| Identification | Back Directory | [Name]
3-(2,2,2-trifluoroacetamido)propanoyl chloride | [CAS]
87639-76-7 | [Synonyms]
N-trifluoroacetyl-β-alanyl chloride
3-(2,2,2-trifluoroacetamido)propanoyl chloride | [Molecular Formula]
C5H5ClF3NO2 | [MDL Number]
MFCD24551336 | [MOL File]
87639-76-7.mol | [Molecular Weight]
203.55 |
| Hazard Information | Back Directory | [Uses]
N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [Biological Activity]
3-(2,2,2-trifluoroacetamido)propanoyl chloride is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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