| Identification | Back Directory | [Name]
Tiospirone | [CAS]
87691-91-6 | [Synonyms]
MJ-13859
Tiospirona
Tiospirone
Tiospironum
Unii-35C6umo5sr
Tiospirone [inn]
Tiospironum [latin]
Tiospirona [spanish]
87691-92-7 (Hydrochloride)
8-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)- | [Molecular Formula]
C24H32N4O2S | [MDL Number]
MFCD00866696 | [MOL File]
87691-91-6.mol | [Molecular Weight]
440.6 |
| Hazard Information | Back Directory | [Uses]
Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2]. | [References]
[1] Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68(1-2):93-8. DOI:10.1016/s0031-9384(99)00141-9
[2] Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81. DOI:10.1211/0022357001774697 |
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