| Identification | Back Directory | [Name]
(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxy-N-(2-hydroxyethyl)icosa-6,8,10,14-tetraenamide | [CAS]
877459-63-7 | [Synonyms]
(5S,12R)-5,12-dihydroxy-N-(2-hydroxyethyl)icosa-6,8,10,14-tetraenamide
(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxy-N-(2-hydroxyethyl)icosa-6,8,10,14-tetraenamide | [Molecular Formula]
C22H37NO4 | [MOL File]
877459-63-7.mol | [Molecular Weight]
379.53 |
| Chemical Properties | Back Directory | [Boiling point ]
617.6±55.0 °C(Predicted) | [density ]
1.038±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 12 mg/ml | [pka]
13.82±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM. LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1. | [Definition]
ChEBI: LTB4 ethanol amide is a N-acylethanolamine. | [in vivo]
Leukotriene B4 ethanolamide (100 nM/mouse/day for 5 days, s.c.) inhibits the tumor progression associated by inflammation in C57BL/6 mice[2]. | Animal Model: | Melanoma tumor in C57BL/6 mouse models[2] | | Dosage: | 100 nM/mouse | | Administration: | s.c., once a day for 5 days | | Result: | Inhibited melanoma tumor growth in mice coinjected with apoptotic Tm1 melanoma cells and a subtumorigenic dose of Tm1. |
| [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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