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877606-63-8

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877606-63-8 Structure

877606-63-8 Structure
IdentificationBack Directory
[Name]

(4S)-3,4-Dihydro-4-phenyl-3-[1-[[3-(trifluoromethoxy)phenyl]methyl]-4-piperidinyl]-2(1H)-quinazolinone
[CAS]

877606-63-8
[Synonyms]

NS986
NS-986
SMP986
NS 986
SMP-986
SMP 986
Afacifenacin
Afacifenacin Fumarate
(4S)-3,4-Dihydro-4-phenyl-3-[1-[[3-(trifluoromethoxy)phenyl]methyl]-4-piperidinyl]-2(1H)-quinazolinone
2(1H)-Quinazolinone, 3,4-dihydro-4-phenyl-3-[1-[[3-(trifluoromethoxy)phenyl]methyl]-4-piperidinyl]-, (4S)-
[Molecular Formula]

C27H26F3N3O2
[MDL Number]

MFCD16619353
[MOL File]

877606-63-8.mol
[Molecular Weight]

481.51
Chemical PropertiesBack Directory
[Boiling point ]

579.1±50.0 °C(Predicted)
[density ]

1.287
[pka]

14.46±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Afacifenacin acts as a sodium/calcium exchanger inhibitor used in the prevention of reperfusion injury associated with restoration of coronary blood flow via surgery.
[in vivo]

Afacifenacin (0.3, 1, 3 mg/kg; Intragastric administration) significantly increases bladder capacity and reduced micturition pressure (MP) in cerebral infarction rats[2].

Animal Model:Male Sprague-Dawley rats (cerebral infarction model)[2]
Dosage:0.3, 1, 3 mg/kg
Administration:Intragastric administration
Result:Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).
Spectrum DetailBack Directory
[Spectrum Detail]

(4S)-3,4-Dihydro-4-phenyl-3-[1-[[3-(trifluoromethoxy)phenyl]methyl]-4-piperidinyl]-2(1H)-quinazolinone(877606-63-8)1HNMR
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