| Identification | Back Directory | [Name]
ADD 4743 | [CAS]
87858-57-9 | [Synonyms]
AD-4743
ADD 4743
5-[[4-[(3-Hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione | [Molecular Formula]
C18H23NO4S | [MOL File]
87858-57-9.mol | [Molecular Weight]
349.44 |
| Hazard Information | Back Directory | [Description]
Add 4743 is an analog of ciglitazone; adipogenic agent. | [Uses]
AD 4743 (ADD 4743) is a metabolite of Ciglitazone (HY-W011220). AD 4743 is an adipogenic agent. AD 4743 induces FPRP accumulation and accumulation of lipid droplets. AD 4743 inhibits cell proliferation of preadipose cells[1][2]. | [References]
[1] Orlicky DJ, et al. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. J Lipid Res. 1998 Jun;39(6):1152-61. PMID:9643346
[2] Hiragun A, et al. Preadipocyte differentiation in vitro: identification of a highly active adipogenic agent. J Cell Physiol. 1988 Jan;134(1):124-30. DOI:10.1002/jcp.1041340115 |
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