| Identification | Back Directory | [Name]
3-Quinolinecarboxylic acid, 7-[(3E)-3-(2-aMino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo- | [CAS]
878592-87-1 | [Synonyms]
JNJ-Q2
Avarofloxacin
(E)-7-(3-(2-Amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1
(E)-7-(3-(2-Amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
3-Quinolinecarboxylic acid, 7-[(3E)-3-(2-aMino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo- | [Molecular Formula]
C21H23F2N3O4 | [MDL Number]
MFCD18633282 | [MOL File]
878592-87-1.mol | [Molecular Weight]
419.42 |
| Chemical Properties | Back Directory | [Boiling point ]
652.3±55.0 °C(Predicted) | [density ]
1.450±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);238.42(Max Conc. mM) | [form ]
Solid | [pka]
6.41±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial agent being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia with oral activity. Avarofloxacin (JNJ-Q2) is an aminoethylidenylpiperidine fluoroquinolone that demonstrates antibacterial effect against numerous Gram-positive bacteria with a mean 0.12 mg/L MIC90 value. Avarofloxacin (JNJ-Q2) has potential for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections[1][2][3]. | [IC 50]
Quinolone | [References]
[1] Jones TM, et al. Focus on JNJ-Q2, a novel fluoroquinolone, for the management of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. DOI:10.2147/IDR.S105620
[2] Kocsis B, et al. Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin. Ann Clin Microbiol Antimicrob. 2016 May 23;15(1):34. DOI:10.1186/s12941-016-0150-4 |
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| Company Name: |
Matrix Scientific
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| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
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