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881191-44-2

881191-44-2 Structure

881191-44-2 Structure
IdentificationBack Directory
[Name]

Otelixizumab
[CAS]

881191-44-2
[Synonyms]

Otelixizumab
Otelixizumab (anti-CD3)
Research Grade Otelixizumab(DHC27702)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes[1].
[in vivo]

Otelixizumab (ChAglyCD3) (100 μg/mouse; i.v.; once) results in durable disease remission dependent on transferable T cell–mediated tolerance in diabetic transgenic mice[1].

Animal Model:BALB/c-huCD3e mice carrying the human CD3e chain[1]
Dosage:100 μg/mouse
Administration:Intravenous injection, once
Result:Induced secretion of lower amounts of IL-6. Exhibited up-regulation of regulatory T cells.
[References]

[1] Kuhn C, et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med. 2011 Feb 2;3(68):68ra10. DOI:10.1126/scitranslmed.3001830
[2] Guglielmi C, et al. Efficacy and safety of otelixizumab use in new-onset type 1 diabetes mellitus. Expert Opin Biol Ther. 2016 Jun;16(6):841-6. DOI:10.1080/14712598.2016.1180363
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