| Chemical Properties | Back Directory | [Boiling point ]
548.0±48.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (241.83 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.06±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively. AZD1940 shows a robust analgesia action[1][2]. | [in vivo]
When given orally to rats, AZD1940 produces a robust analgesia in different models of inflammatory and neuropathic pain[1][2].
For AZD1940, low brain uptake at analgesic doses has been demonstrated in both rats and primates[1]. | [IC 50]
hCB1-R: 7.93 (pKi); hCB2-R: 9.06 (pKi) | [storage]
Store at -20°C | [References]
[1] Jarkko Kalliom?ki, et al. Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):212-8. DOI:10.1111/1440-1681.12051
[2] Magnus Schou, et al. Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate. Nucl Med Biol. 2013 Apr;40(3):410-4. DOI:10.1016/j.nucmedbio.2012.10.011 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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