| Identification | Back Directory | [Name]
2-[[2-(Carbamoylmethylamino)ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester | [CAS]
88150-59-8 | [Synonyms]
UK-51656
2-[[2-(Carbamoylmethylamino)ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester
3,5-Pyridinedicarboxylic acid, 2-[[2-[(2-amino-2-oxoethyl)amino]ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester | [Molecular Formula]
C22H28ClN3O6 | [MDL Number]
MFCD00889201 | [MOL File]
88150-59-8.mol | [Molecular Weight]
465.93 |
| Hazard Information | Back Directory | [Uses]
UK51656 is a calcium antagonist with IC50 of 4 nM. | [in vivo]
UK51656 has an elimination half-life of 4.7 h, which is consistent with its duration of action in the anesthetized dog. The effect of UK51656 on coronary vascular resistance, has markedly long durations, being over 5 h[1]. | [storage]
Store at -20°C | [References]
[1] D Alker, et al. Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33 DOI:10.1021/jm00164a019
[2] Alker D, et al. Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33(2):585-91. |
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