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881895-59-6

881895-59-6 Structure

881895-59-6 Structure
IdentificationBack Directory
[Name]

6-O-2-Propyn-1-yl-D-galactose
[CAS]

881895-59-6
[Synonyms]

6-O-2-Propyn-1-yl-D-galactose
D-Galactose, 6-O-2-propyn-1-yl-
[Molecular Formula]

C9H14O6
[MDL Number]

MFCD32201130
[MOL File]

881895-59-6.mol
[Molecular Weight]

218.2
Chemical PropertiesBack Directory
[Boiling point ]

479.7±45.0 °C(Predicted)
[density ]

1.398±0.06 g/cm3(Predicted)
[pka]

12.45±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

6-O-2-Propyn-1-yl-D-galactose is a nonclaevable glycolinker for the functionalization of cytotoxic agents and applications in antibody-agent conjugation. 6-O-2-Propyn-1-yl-D-galactose is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[IC 50]

Non-cleavable Linker
[References]

[1] Ekholm FS, et al. Introducing Glycolinkers for the Functionalization of Cytotoxic Drugs and Applications in Antibody-Drug Conjugation Chemistry. ChemMedChem. 2016 Nov 21;11(22):2501-2505. DOI:10.1002/cmdc.201600372
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