| Identification | Back Directory | [Name]
iMDK | [CAS]
881970-80-5 | [Synonyms]
iMDK
3-[2-(4-Fluoro-benzyl)-imidazo[2,1-b]thiazol-6-yl]-chromen-2-one
2H-1-Benzopyran-2-one, 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-
inhibit,iMDK,midkine,factor,PI3K,NSCLC,growth,Inhibitor,Phosphoinositide 3-kinase,MDK | [Molecular Formula]
C21H13FN2O2S | [MDL Number]
MFCD07528492 | [MOL File]
881970-80-5.mol | [Molecular Weight]
376.4 |
| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
Limited solubility | [form ]
Solid | [pka]
5.71±0.40(Predicted) | [color ]
Off-white to yellow | [InChI]
InChI=1S/C21H13FN2O2S/c22-15-7-5-13(6-8-15)9-16-11-24-12-18(23-21(24)27-16)17-10-14-3-1-2-4-19(14)26-20(17)25/h1-8,10-12H,9H2 | [InChIKey]
IWFKQTWYILKFGE-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2=CC=CC=C2C=C1C1=CN2C=C(CC3=CC=C(F)C=C3)SC2=N1 |
| Hazard Information | Back Directory | [Uses]
iMDK is a small molecule inhibitor used to bind to midkine (MDK), a heparin binding growth factor that is expressed in malignant tumors. | [Biological Activity]
Cell permeable: yes''Primary Target
Midkine''Reversible: yes | [in vivo]
The combination treatment of iMDK ( (9 mg/kg/day; intraperitoneally injected with 100 μl) and PD0325901 (5 mg/kg; orally administered) effectively reduced lung tumor growth in a xenograft mouse model[1]. | Animal Model: | female BALB/c nude mice (6 week old) bearing H441 human lung cancer xenografts[1] | | Dosage: | iMDK (9 mg/kg) and PD0325901 (5 mg/kg) | | Administration: | Intraperitoneally injected with 100 μL iMDK everyday and/or orally administered PD0325901 five times per week (on days 1, 2, 3, 4, 5, 7, 8, 9, 10, 11) | | Result: | Reduced significantly volume of the tumors derived from H441 lung adenocarcinoma cells after the combination treatment with iMDK and PD0325901 compared to that of single compound in a xenograft mouse model.
|
| [storage]
Store at +4°C |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|